Description

Etretinate is a synthetic aromatic retinoid derivative, a compound of significant interest in pharmaceutical research and development. Its primary value lies in its potent biological activity, which has been extensively studied for modulating cell growth and differentiation. This makes it a critical intermediate and reference standard for researchers in the life sciences sector, particularly those focused on dermatology, oncology, and molecular biology. Global suppliers and research institutions require high-purity Etretinate CAS NO 54350-48-0 for analytical, developmental, and quality control purposes.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for quality control and assay validation in drug manufacturing and regulatory compliance.
• Biochemical Research: Used as a potent tool compound in academic and industrial laboratories to study retinoid receptor pathways, gene expression, and cellular differentiation mechanisms.
• Active Pharmaceutical Ingredient (API) Intermediate: Acts as a key synthetic precursor in the development and production of advanced retinoid-based therapeutics.
• Dermatology Research: Employed in preclinical studies investigating treatments for severe skin disorders such as psoriasis and keratinization diseases.
• Oncology Research: Utilized in vitro and in vivo studies to explore its effects on cancer cell proliferation and apoptosis.
• Analytical Chemistry: Provides a high-purity standard for method development and calibration in chromatographic systems (HPLC, LC-MS) for accurate compound identification and quantification.

Basic Information

Product Name	Etretinate
CAS No.	54350-48-0
Molecular Formula	C23H30O3
Molecular Weight	354.49 g/mol
Synonyms	Ethyl All-trans-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoate; Ro 10-9359; Tigason; Arotinoid Ethyl Ester; Ethyl Retinoate; All-trans-Etretinate; 9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic Acid Ethyl Ester
EINECS	259-125-7

Quality Control

Our Etretinate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.