Description

Amsacrine Hydrochloride is a synthetic antineoplastic agent belonging to the acridine class. Its primary value lies in its potent topoisomerase II inhibitory activity, which makes it a critical compound for oncology research and development. This product is essential for pharmaceutical R&D laboratories, academic institutions, and manufacturers focused on developing and studying chemotherapeutic agents.

Application

• Oncology Research & Drug Development: As a key reference standard and active pharmaceutical ingredient (API) in the study of antineoplastic mechanisms and the development of new cancer therapies.
• Biochemical Studies: Used in vitro to investigate DNA intercalation, topoisomerase II inhibition, and apoptosis induction in various cancer cell lines.
• Pharmaceutical Intermediates: Serves as a crucial synthetic intermediate in the preparation of more complex therapeutic agents or prodrugs.
• Clinical Research Material: Employed in preclinical studies to evaluate efficacy, pharmacokinetics, and toxicology profiles.
• Analytical Standard: Used as a high-purity standard for quality control (QC) and analytical method development (e.g., HPLC, LC-MS) in pharmaceutical manufacturing.

Basic Information

Product Name	Amsacrine Hydrochloride
CAS No.	54301-15-4
Molecular Formula	C21H20ClN3O3S • HCl
Molecular Weight	470.83 g/mol (for hydrochloride salt)
Synonyms	m-AMSA Hydrochloride; Acridinyl Anisidide Hydrochloride; 4'-(9-Acridinylamino)methanesulfon-m-anisidide Hydrochloride; NSC-249992; Amsidine Hydrochloride; CI-880 Hydrochloride; SN-11841 Hydrochloride
EINECS	Contact for details

Quality Control

Our Amsacrine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing results from HPLC, NMR, and other relevant pharmacopeial tests.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and in original packaging until use to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.