Description

3-Deazauridine 5'-Triphosphate is a chemically modified nucleotide analog, specifically a triphosphate derivative of 3-deazauridine. This compound is a critical biochemical tool for studying and manipulating nucleic acid metabolism and enzymatic processes. It is primarily utilized by researchers and developers in the fields of molecular biology, enzymology, and pharmaceutical discovery. Its unique structure makes it valuable for probing the mechanisms of RNA synthesis and related enzymes.

Application

• Enzymology Research: Used as a substrate or inhibitor to study the activity and kinetics of RNA polymerases, reverse transcriptases, and other nucleotide-processing enzymes.
• Nucleic Acid Synthesis: Employed in the synthesis of modified RNA strands to investigate structure-function relationships and RNA stability.
• Antiviral & Anticancer Research: Serves as a precursor for investigating nucleoside analogs with potential therapeutic activity against viral infections and cancer.
• Biochemical Assay Development: Acts as a key component in developing high-throughput screening assays for drug discovery targeting nucleic acid pathways.
• Metabolic Pathway Studies: Used to trace and understand cellular nucleotide salvage and metabolic pathways.
• Structural Biology: Aids in X-ray crystallography and NMR studies to determine the three-dimensional structures of enzyme-substrate complexes.

Basic Information

Product Name	3-Deazauridine 5'-Triphosphate
CAS No.	54267-16-2
Molecular Formula	C12H18N3O15P3
Molecular Weight	537.19 g/mol
Synonyms	3-Deaza-UTP; 3-Deazauridine triphosphate; 1-(β-D-Ribofuranosyl)-1,4-dihydro-2,4-dioxo-1,3,5-triazine 5'-Triphosphate; 3-Deazauridine 5'-(tetrahydrogen triphosphate); 3-DU TP; 3-Deaza-uridine-5'-triphosphate; 3-Deazauridine-5'-triphosphoric acid
EINECS	Contact for details

Quality Control

Our 3-Deazauridine 5'-Triphosphate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is analyzed using advanced techniques including HPLC and NMR to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.