Description

Letosteine is a synthetic sulfur-containing amino acid derivative with mucolytic and antioxidant properties. It is a key active pharmaceutical ingredient (API) valued for its ability to reduce the viscosity of mucus, making it a critical component in the formulation of respiratory therapeutics. This compound is primarily utilized by pharmaceutical manufacturers and research institutions developing treatments for chronic obstructive pulmonary disease (COPD), bronchitis, and other respiratory conditions characterized by excessive or thick mucus.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription and over-the-counter mucolytic medications for respiratory tract disorders.
• Chronic Bronchitis Treatment: Formulated into tablets, syrups, and effervescent granules to alleviate symptoms by breaking down disulfide bonds in mucus glycoproteins.
• COPD Management: Incorporated into therapeutic regimens to improve lung function and reduce exacerbations in patients with chronic obstructive pulmonary disease.
• Cystic Fibrosis Supportive Care: Used as part of a comprehensive treatment plan to help clear airway secretions.
• Sinusitis and Rhinitis: Found in formulations aimed at reducing the viscosity of nasal secretions.
• Antioxidant Research: Investigated in preclinical studies for its free radical scavenging and cellular protective effects due to its thiol group.
• Veterinary Pharmaceuticals: Applied in veterinary medicine for respiratory conditions in animals.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical laboratories.

Basic Information

Product Name	Letosteine
CAS No.	53943-88-7
Molecular Formula	C5H9NO3S
Molecular Weight	163.19 g/mol
Synonyms	L-Letosteine; (2R)-2-Amino-4-[(carboxymethyl)thio]butanoic acid; (R)-2-Amino-4-[(carboxymethyl)thio]butyric acid; Letosteinum; Letosteina; L-2-Amino-4-[(carboxymethyl)thio]butanoic acid; L-2-Amino-4-[(carboxymethyl)sulfanyl]butanoic acid; L-Letosteine
EINECS	Contact for details

Quality Control

Our Letosteine is manufactured under strict quality management systems, ensuring it meets the stringent requirements for pharmaceutical active ingredients. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling, to guarantee compliance with pharmacopeial standards such as USP and EP. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and moisture. For long-term storage, consider conditions under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Specific Rotation	+18.0° to +22.0° (c=1 in water)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.