Description

4-Ethyl-Piperazine-1-Carbonyl Chloride is a versatile and highly reactive chemical building block, primarily used as an intermediate in the synthesis of complex organic molecules. Its value lies in its ability to introduce the 4-ethylpiperazine moiety, a privileged structural motif found in many active pharmaceutical ingredients. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system and as kinase inhibitors.
• Agrochemical Synthesis: Used in the research and production of novel pesticides and herbicides, where the piperazine ring contributes to biological activity.
• Organic Synthesis Reagent: Serves as a versatile acylating agent in research laboratories for introducing the N-ethylpiperazine carboxamide functional group into target molecules.
• Ligand and Catalyst Development: Employed in the creation of novel ligands for metal catalysis and in the development of organocatalysts.
• Polymer Chemistry: Can be used as a monomer or modifier in the synthesis of specialty polymers with specific functional properties.
• Chemical Research: Fundamental reagent in medicinal chemistry and process chemistry for structure-activity relationship (SAR) studies and scale-up.

Basic Information

Product Name	4-Ethyl-Piperazine-1-Carbonyl Chloride
CAS No.	53788-12-8
Molecular Formula	C7H13ClN2O
Molecular Weight	176.65 g/mol
Synonyms	1-(Chlorocarbonyl)-4-ethylpiperazine; 4-Ethylpiperazine-1-carbonyl chloride; 4-Ethyl-1-piperazinecarbonyl chloride; 1-Piperazinecarbonyl chloride, 4-ethyl-; N-(Chlorocarbonyl)-N'-ethylpiperazine; 4-Ethylpiperazinyl-1-carbonyl chloride; N-Carboxy-4-ethylpiperazine chloride
EINECS	Contact for details

Quality Control

Our 4-Ethyl-Piperazine-1-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR, to ensure it meets the high standards required for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.