Description

3-Azido-L-Phenylalanine is a non-canonical amino acid derivative featuring a reactive azido group on the aromatic side chain. This compound matters as a critical building block in bioorthogonal chemistry, enabling site-specific labeling and conjugation of biomolecules through click chemistry reactions. It is primarily needed by researchers and manufacturers in pharmaceutical development, chemical biology, and proteomics for applications such as antibody-drug conjugate (ADC) synthesis, protein engineering, and metabolic labeling.

Application

• Key precursor for synthesizing antibody-drug conjugates (ADCs) and other bioconjugates.
• Metabolic incorporation into proteins for subsequent bioorthogonal labeling and imaging studies.
• Building block for peptide and protein engineering to introduce novel chemical handles.
• Tool compound in chemical biology research for studying protein function and interactions.
• Intermediate in the development of novel therapeutics and diagnostic agents.
• Substrate for click chemistry reactions, including copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC).

Basic Information

Product Name	3-Azido-L-Phenylalanine
CAS No.	53774-67-7
Molecular Formula	C9H10N4O2
Molecular Weight	206.20 g/mol
Synonyms	L-3-Azidophenylalanine; (2S)-2-Amino-3-(3-azidophenyl)propanoic acid; Azido-Phe; 3-N3-Phe; Azidophenylalanine; 3-Azido-DL-phenylalanine (related); AHA (Azidohomoalanine, related analog); Click chemistry amino acid; Bioorthogonal amino acid
EINECS	Contact for details

Quality Control

Our 3-Azido-L-Phenylalanine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. The material is light-sensitive and easily oxidized. Keep the container in a dry, cool, and well-ventilated place. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 98.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.