Description

8-Azidoadenosine 5'-Triphosphate, Sodium Salt is a chemically modified nucleotide analog where an azido group replaces the hydroxyl at the 8-position of the adenine ring. This compound is a critical photoaffinity labeling reagent and a cross-linking agent, enabling the study of ATP-binding proteins and nucleic acid interactions. It is essential for researchers and developers in biochemistry, molecular biology, and pharmaceutical discovery who require tools for probing enzyme mechanisms and mapping binding sites.

Application

• Photoaffinity Labeling: Used as a photoactivatable probe to irreversibly label and identify ATP-binding sites in proteins and enzymes.
• Bioconjugation and Cross-linking: Serves as a key reagent for "click chemistry" applications, facilitating the attachment of biomolecules via its reactive azide group.
• Enzyme Mechanism Studies: Employed to investigate the kinetics and catalytic mechanisms of kinases, ATPases, and other ATP-dependent enzymes.
• Nucleic Acid Research: Used in the synthesis of modified oligonucleotides for structural studies and the development of diagnostic probes.
• Drug Discovery: A vital tool in high-throughput screening assays to identify and characterize novel inhibitors of ATP-binding targets.
• Structural Biology: Aids in X-ray crystallography and cryo-EM studies by providing a means to trap and stabilize protein-ligand complexes.

Basic Information

Product Name	8-Azidoadenosine 5'-Triphosphate, Sodium Salt
CAS No.	53696-59-6
Molecular Formula	C10H12N8O13P3Nax (x≈3)
Molecular Weight	Approx. 607.1 (Free acid, anhydrous basis)
Synonyms	8-N3-ATP; 8-Azido-ATP; 8-Azidoadenosine triphosphate sodium salt; Adenosine 5'-(tetrahydrogen triphosphate), 8-azido-, sodium salt; 8-Azido-adenosine-5'-triphosphate; ATP-γ-azido analog; Photoactivatable ATP; Clickable ATP
EINECS	Contact for details

Quality Control

Our 8-Azidoadenosine 5'-Triphosphate, Sodium Salt is manufactured under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability parameters. We adhere to ISO 9001 quality management principles, and our analytical methods are validated to meet the exacting standards of the life sciences industry.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term stability, aliquoting is recommended to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, buffer solutions
Biological Activity	Functional in standard kinase/ATPase assays

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.