Description

Propanoyl Chloride, 2-(Acetyloxy)-, (2R)- is a chiral, highly reactive acid chloride derivative, primarily used as a key chiral building block in sophisticated organic synthesis. Its value lies in its ability to introduce a specific stereocenter and an acetyl-protected hydroxyl group in a single, efficient step, enabling the production of enantiomerically pure intermediates. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced material sectors who require high-purity, stereochemically defined reagents for complex molecule construction.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of enantiomerically pure drugs targeting neurological and metabolic disorders.
• Agrochemical Synthesis: Used in the production of chiral pesticides and herbicides, where specific stereochemistry is crucial for biological activity and environmental safety.
• Asymmetric Catalysis Research: Serves as a substrate or ligand precursor in the development and study of new asymmetric catalytic reactions.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances that require precise stereochemical control.
• Polymer Modification: Acts as a functional monomer or grafting agent to introduce chiral centers or reactive sites into polymer chains for advanced material applications.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic chemistry and for synthesizing complex natural product analogs.

Basic Information

Item	Details
Product Name	Propanoyl Chloride, 2-(Acetyloxy)-, (2R)-
CAS No.	53636-19-4
Molecular Formula	C5H7ClO3
Molecular Weight	150.56 g/mol
Synonyms	(R)-2-(Acetyloxy)propanoyl chloride; (R)-2-Acetoxypropionyl chloride; D-2-Acetoxypropionyl chloride; (2R)-2-Acetyloxypropanoyl chloride; Lactic acid acetate chloride (R-form); (R)-O-Acetyllactoyl chloride; (R)-1-Chloro-1-oxopropan-2-yl acetate
EINECS	Contact for details

Quality Control

Every batch of our (R)-2-(Acetyloxy)propanoyl chloride is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure high chemical and chiral purity. We provide comprehensive Certificates of Analysis (COA) detailing assay, enantiomeric excess (e.e.), and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliable performance and traceability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon). Due to its moisture-sensitive and strong acid/organic solvent nature, keep the container tightly sealed and handle under dry conditions to prevent hydrolysis and degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.