Description

Pyrazole-1-Carbonyl Chloride is a versatile and highly reactive organic acid chloride derivative of pyrazole. This compound serves as a critical building block in advanced organic synthesis, enabling the efficient introduction of the pyrazole-1-carbonyl moiety into target molecules. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing heterocyclic amide functionalities.
• Agrochemical Synthesis: Used in the production of modern pesticides, herbicides, and fungicides where the pyrazole scaffold imparts specific biological activity.
• Peptide Mimetics & Bioconjugation: Acts as an acylating agent for modifying peptides or creating peptide-like structures in drug discovery.
• Material Science Research: Employed in the development of novel polymers, ligands for metal-organic frameworks (MOFs), and specialty chemicals.
• Custom Synthesis & Contract Manufacturing: A fundamental reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	Pyrazole-1-Carbonyl Chloride
CAS No.	53355-55-8
Molecular Formula	C4H3ClN2O
Molecular Weight	130.53 g/mol
Synonyms	1H-Pyrazole-1-carbonyl chloride; Pyrazole-1-carboxylic acid chloride; 1-Pyrazolecarbonyl chloride; Pyrazolecarboxylic acid chloride; 1-Carboxypyrazole chloride; Pyrazolyl-1-carbonyl chloride; 1-Pyrazolyl carbonyl chloride
EINECS	Contact for details

Quality Control

Our Pyrazole-1-Carbonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Production adheres to cGMP guidelines where applicable, and each lot is accompanied by a comprehensive Certificate of Analysis (COA). The COA provides detailed results for identity, purity, and impurity profiles, typically determined by techniques such as NMR, HPLC, and titration.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and reactive nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C). Keep away from moisture, strong bases, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.