Description

Bis(Pentafluorophenyl)Chlorophosphine Sulfide is a specialized organophosphorus compound featuring pentafluorophenyl groups, which confer unique reactivity and stability. This high-value intermediate is critical for synthesizing advanced ligands and catalysts used in cross-coupling reactions and materials science. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in fluorine-containing drug candidates.
• Catalyst & Ligand Precursor: Serves as a precursor for sophisticated phosphine-based ligands used in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Negishi).
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides where fluorine atoms enhance biological activity and environmental stability.
• Materials Science: Employed in the synthesis of monomers and additives for high-performance polymers, including flame retardants and specialty resins.
• Chemical Synthesis: A versatile reagent for introducing the (pentafluorophenyl)phosphinothioyl group into target molecules in organic and organometallic chemistry.

Basic Information

Product Name	Bis(Pentafluorophenyl)Chlorophosphine Sulfide
CAS No.	53327-28-9
Molecular Formula	C₁₂ClF₁₀PS
Molecular Weight	464.60 g/mol
Synonyms	Chlorobis(pentafluorophenyl)phosphine sulfide; Bis(2,3,4,5,6-Pentafluorophenyl)chlorophosphine sulfide; (Pentafluorophenyl)phosphonothioic chloride; Chloridobis(pentafluorophenyl)-λ⁵-phosphanethione; NSC 339063; Chlorobis(pentafluorophenyl)phosphine thio
EINECS	Contact for details

Quality Control

Our Bis(Pentafluorophenyl)Chlorophosphine Sulfide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including NMR (¹H, ¹⁹F, ³¹P), HPLC, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) to prevent degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
¹H NMR	Conforms
³¹P NMR	Conforms
¹⁹F NMR	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.