Description

n-Phenyl-Guanosine 2',3',5'-Triacetate is a chemically modified nucleoside derivative, specifically a protected form of guanosine. This compound is a crucial intermediate in oligonucleotide synthesis and pharmaceutical research, where protecting groups are essential for controlling reactivity during complex chemical transformations. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in the production of nucleoside analogs, antiviral agents, and modified RNA/DNA sequences.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel nucleoside-based antiviral and anticancer drugs.
• Oligonucleotide Synthesis: Serves as a protected monomer for the solid-phase or solution-phase synthesis of modified RNA and DNA strands.
• Biochemical Research: Used in studies of enzyme mechanisms, nucleic acid chemistry, and as a precursor for fluorescent or labeled nucleosides.
• Prodrug Development: Acts as a masked form of guanosine to improve bioavailability or target specificity in prodrug formulations.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	n-Phenyl-Guanosine 2',3',5'-Triacetate
CAS No.	53296-13-2
Molecular Formula	C24H25N5O8
Molecular Weight	511.49 g/mol
Synonyms	Guanosine, 2',3',5'-tri-O-acetyl-N-phenyl-; N-Phenyl-2',3',5'-tri-O-acetylguanosine; 9-[(2R,3R,4R,5R)-3,4-Diacetyloxy-5-(acetyloxymethyl)oxolan-2-yl]-6-(phenylamino)-1H-purin-2-one; 2',3',5'-Tri-O-acetyl-N-phenylguanosine; N-Phenyltriacetylguanosine; Phenyl-Guo(Ac)3; Protected N-phenylguanosine
EINECS	Contact for details

Quality Control

Our n-Phenyl-Guanosine 2',3',5'-Triacetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.