Description

Betnovate-N CAS NO 53262-69-4 is a topical pharmaceutical preparation combining a potent corticosteroid with an antimicrobial agent. This formulation is specifically engineered to provide dual-action therapy for inflammatory skin conditions complicated by secondary bacterial or fungal infections. It is a critical material for pharmaceutical manufacturers developing dermatological creams and ointments targeting markets requiring advanced topical treatments. The product's efficacy and stability are paramount for ensuring final drug product performance and patient safety.

Application

• Primary raw material for the manufacture of topical corticosteroid creams and ointments.
• Used in compounding pharmacies for specialized dermatological preparations.
• Key ingredient in products treating inflammatory skin conditions such as eczema, psoriasis, and dermatitis where infection is present or likely.
• Applied in the development of prescription-strength dermatological products for global pharmaceutical markets.
• Serves as a reference standard in quality control laboratories for assay and impurity profiling.
• Utilized in clinical research for developing new topical combination therapies.

Basic Information

Product Name	Betnovate-N
CAS No.	53262-69-4
Molecular Formula	C24H31FO6 • C18H35ClN2
Molecular Weight	Betamethasone 17-valerate: 476.59 g/mol; Neomycin sulfate: 908.87 g/mol (as neomycin B)
Synonyms	Betamethasone Valerate and Neomycin Sulfate Cream; Betamethasone 17-Valerate with Neomycin; Betnovate-N Cream; Betamethasone/Neomycin Topical; GSK Betnovate-N; (11β,16β)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 17-valerate combined with Neomycin B sulfate; Topical corticosteroid-antibiotic combination.
EINECS	Contact for details

Quality Control

Our Betnovate-N is manufactured under strict quality management systems. Each batch is tested to ensure it meets stringent specifications for identity, potency, purity, and microbiological quality, aligning with major pharmacopeial standards (e.g., BP, USP). A comprehensive Certificate of Analysis (COA) documenting all test results, including assay of both active components and limits for related substances, is provided with every shipment to guarantee supply chain integrity and regulatory compliance for our B2B partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from excessive heat and direct sunlight.

Specification

Item	Specification
Appearance	White to off-white cream
Identification (HPLC/IR)	Conforms to standard
Assay (Betamethasone Valerate)	90.0% - 110.0% of label claim
Assay (Neomycin Sulfate)	90.0% - 120.0% of label claim
Related Substances (HPLC)	Meets pharmacopeial limits
Microbial Limits	Absence of specified pathogens; Total viable count within limits
pH	5.0 - 7.0
Uniformity of Dosage Units	Conforms to USP requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.