Description

Bis(Trimethylsilyl)=(1-Amino-2-Methylpropyl) Phosphonate is a specialized organosilicon phosphonate compound. It serves as a valuable synthetic intermediate and protecting group reagent in advanced organic synthesis. This product is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those containing phosphorus or requiring amino-protected functionalities.
• Peptide Mimetics & Prodrug Synthesis: Used to create phosphonate-based analogs of amino acids and peptides, which are important for developing enzyme inhibitors and prodrug strategies.
• Organocatalyst & Ligand Precursor: Acts as a precursor for chiral phosphonate ligands and catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and surface-modifying agents where phosphonate groups impart specific properties.
• Agrochemical Synthesis: Intermediate in the production of advanced herbicides, plant growth regulators, and other agrochemicals with phosphonate backbones.
• Protecting Group Chemistry: The trimethylsilyl groups can be used for the temporary protection of phosphonic acid functionalities during multi-step synthetic sequences.

Basic Information

Product Name	Bis(Trimethylsilyl)=(1-Amino-2-Methylpropyl) Phosphonate
CAS No.	53044-33-0
Molecular Formula	C13H34NO3PSi2
Molecular Weight	339.57 g/mol
Synonyms	1-Amino-2-methylpropylphosphonic Acid Bis(trimethylsilyl) Ester; (1-Amino-2-methylpropyl)phosphonic Acid Bis(trimethylsilyl) Ester; Phosphonic Acid, P-(1-Amino-2-methylpropyl)-, Bis(trimethylsilyl) Ester; Bis(trimethylsilyl) (1-Amino-2-methylpropyl)phosphonate; TMS-Protected Ibuprofen Aminophosphonate; (α-Aminoisobutyl)phosphonic Acid Bis(TMS) Ester
EINECS	Contact for details

Quality Control

Our Bis(Trimethylsilyl)=(1-Amino-2-Methylpropyl) Phosphonate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical specifications are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture ingress and decomposition. For long-term storage, consider using an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.