Description

2H-Pyran-4-Carbonyl Chloride, 3,4-Dihydro- (9Ci) is a versatile and highly reactive organic intermediate, specifically an acid chloride derivative of a dihydropyran. This compound matters for its role as a crucial building block in sophisticated organic synthesis, enabling the efficient introduction of the 3,4-dihydro-2H-pyran-4-carbonyl moiety. It is primarily needed by research chemists and process development teams in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures, including potential active pharmaceutical ingredients (APIs) and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting heterocyclic compounds.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where the dihydropyran scaffold imparts specific biological activity.
• Fine Chemical Manufacturing: Serves as a precursor for dyes, fragrances, and other high-value specialty chemicals requiring functionalized pyran rings.
• Polymer Science: Can be utilized to create monomers or cross-linking agents for specialty polymers with tailored properties.
• Academic & Contract Research: Essential for methodological development and exploratory synthesis in university and CRO (Contract Research Organization) laboratories.
• Peptide & Conjugate Chemistry: The reactive carbonyl chloride group allows for efficient coupling reactions in peptide mimetics or bioconjugate synthesis.

Basic Information

Product Name	2H-Pyran-4-Carbonyl Chloride, 3,4-Dihydro- (9Ci)
CAS No.	53035-93-1
Molecular Formula	C6H7ClO2
Molecular Weight	146.57 g/mol
Synonyms	3,4-Dihydro-2H-pyran-4-carbonyl chloride; 4-Chlorocarbonyl-3,4-dihydro-2H-pyran; Dihydro-2H-pyran-4-carbonyl chloride; Tetrahydro-4-pyranoyl chloride; 3,4-Dihydro-2H-pyran-4-carboxylic acid chloride; 4-Pyrancarbonyl chloride, 3,4-dihydro-
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and process chemistry. Each batch is characterized to confirm identity and purity, with critical parameters monitored via analytical techniques such as NMR, HPLC, and titration. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent derivative, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from moisture, heat, and incompatible materials such as bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.