Description

Nanaomycin A CAS NO 52934-83-5 is a potent quinone-based antibiotic isolated from *Streptomyces rosa* subspecies *notoensis*. This compound is valued for its significant biological activity, particularly as a selective inhibitor of DNA polymerase alpha. It serves as a critical research tool in molecular biology and pharmaceutical development for studying DNA replication and as a lead compound for novel antimicrobial and anticancer agents. Key industries utilizing this material include academic and pharmaceutical R&D, biotechnology, and fine chemical synthesis.

Application

• Biochemical Research: Used as a selective inhibitor of eukaryotic DNA polymerase alpha in enzymatic studies and mechanism-of-action research.
• Antimicrobial Agent Development: Serves as a reference standard and lead compound for developing new antibiotics against Gram-positive bacteria and fungi.
• Oncology Research: Investigated for its antiproliferative effects and potential as a chemotherapeutic agent or a model for synthesizing novel anticancer drugs.
• Pharmaceutical Intermediates: Acts as a key chiral building block in the synthetic pathways of complex natural products and bioactive molecules.
• Cell Biology Studies: Employed to inhibit DNA replication in cell culture models to study cell cycle progression and checkpoint mechanisms.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of related pharmaceutical products.

Basic Information

Product Name	Nanaomycin A
CAS No.	52934-83-5
Molecular Formula	C₂₃H₂₄O₈
Molecular Weight	428.43 g/mol
Synonyms	Nanaomycin A; Antibiotic U-58,431; U-58,431; 5,8-Dihydroxy-6-methoxy-3-methyl-1,4-naphthoquinone; 3-Methyl-5,8-dihydroxy-6-methoxy-1,4-naphthoquinone; (5S,8S,10R)-5,8,10-Trihydroxy-6-methoxy-3-methyl-1,4-anthraquinone; NSC 339586
EINECS	Contact for details

Quality Control

Our Nanaomycin A is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing all specifications and test results to ensure compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The material should be allowed to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.