Description

2-Hydroxy-2,2-Diphenylacetyl Chloride is a specialized acid chloride derivative of diphenylglycolic acid, serving as a crucial building block in advanced organic synthesis. Its primary value lies in its high reactivity, enabling the efficient introduction of the diphenylhydroxyacetyl moiety into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and complex fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of anticholinergic agents, muscle relaxants, and other bioactive molecules.
• Agrochemical Synthesis: Used in the production of advanced herbicides and plant growth regulators.
• Peptide Mimetics & Prodrug Development: Facilitates the creation of ester and amide-based prodrugs and peptide analogs.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for specialty polymers with specific functional properties.
• Ligand & Catalyst Preparation: Employed in the synthesis of chiral ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D exploring new synthetic methodologies.

Basic Information

Product Name	2-Hydroxy-2,2-Diphenylacetyl Chloride
CAS No.	52905-45-0
Molecular Formula	C14H11ClO2
Molecular Weight	246.69 g/mol
Synonyms	Diphenylglycolyl Chloride; α-Hydroxydiphenylacetyl Chloride; Benzilic Acid Chloride; 2,2-Diphenyl-2-hydroxyacetyl Chloride; (Hydroxydiphenylacetyl) Chloride; O,O-Diphenylglycolic Chloride; Hydroxydiphenylacetic Acid Chloride
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-2,2-Diphenylacetyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 96.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.