Description

1,4,5-Tris(Trimethylsilyl)-1H-Pyrazole is a highly functionalized organosilicon compound, specifically a silylated pyrazole derivative. This advanced intermediate is valued for its role as a versatile protecting group and a key building block in sophisticated organic synthesis. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those requiring silicon-containing functional groups.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the pyrazole core and silyl groups can impart specific biological activity and stability.
• Organometallic Chemistry: Acts as a precursor or ligand in the preparation of metal-organic complexes and catalysts for specialized reactions.
• Material Science: Employed in the research and development of advanced materials, such as silicon-based polymers or surface-modifying agents.
• Organic Synthesis Building Block: Utilized as a protected pyrazole derivative in multi-step synthetic routes, enabling complex transformations that are sensitive to other functional groups.

Basic Information

Product Name	1,4,5-Tris(Trimethylsilyl)-1H-Pyrazole
CAS No.	52805-98-8
Molecular Formula	C12H28N2Si3
Molecular Weight	284.62 g/mol
Synonyms	1H-Pyrazole, 1,4,5-tris(trimethylsilyl)-; Tris(trimethylsilyl)pyrazole; 1,4,5-Tris(trimethylsilyl)pyrazole; TTMSP; 1,4,5-Tris-trimethylsilyl-1H-pyrazole; Pyrazole, 1,4,5-tris(trimethylsilyl)-; 1,4,5-TMS-pyrazole
EINECS	Contact for details

Quality Control

Our 1,4,5-Tris(Trimethylsilyl)-1H-Pyrazole is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and GC analysis, to ensure high purity and consistency. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.