Description

1,3,4-Tris(Trimethylsilyl)-1H-Pyrazole is a highly functionalized organosilicon compound, serving as a versatile silylating agent and protected intermediate in advanced organic synthesis. Its core value lies in providing steric protection and modifying reactivity, which is critical for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries, where precise control over synthetic pathways is paramount.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly where the pyrazole moiety or silyl protection is required for drug discovery and development.
• Agrochemical Synthesis: Serves as a key building block for creating novel herbicides, fungicides, and insecticides with enhanced efficacy and stability.
• Organometallic Chemistry: Acts as a ligand precursor or a protecting group in the preparation of metal complexes and catalysts for specialized reactions.
• Advanced Material Research: Employed in the development of silicon-containing polymers, dendrimers, and other functional materials with tailored properties.
• Cross-Coupling Reactions: Functions as a reagent in palladium-catalyzed and other cross-coupling methodologies to introduce the silylated pyrazole group into target molecules.
• Nucleoside & Nucleotide Chemistry: Utilized for the protection of heterocyclic bases during the synthesis of modified nucleosides and oligonucleotides.

Basic Information

Product Name	1,3,4-Tris(Trimethylsilyl)-1H-Pyrazole
CAS No.	52805-97-7
Molecular Formula	C12H28N2Si3
Molecular Weight	284.62 g/mol
Synonyms	1H-Pyrazole, 1,3,4-tris(trimethylsilyl)-; Tris(trimethylsilyl)pyrazole; 1,3,4-Tris(trimethylsilyl)pyrazole; 1,3,4-Tri(trimethylsilyl)-1H-pyrazole; Pyrazole, 1,3,4-tris(trimethylsilyl)-; TMS-Pyrazole derivative; 1,3,4-Tri-TMS-pyrazole
EINECS	Contact for details

Quality Control

Our 1,3,4-Tris(Trimethylsilyl)-1H-Pyrazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.