Description

3-(3-Amino-3-Carboxypropyl)-1-Methylpseudouridine is a high-purity, chemically modified nucleoside derivative of significant importance in advanced pharmaceutical and biotechnology research. This compound serves as a critical building block for the synthesis of modified mRNA, enhancing its stability and translational efficiency. It is primarily required by research institutions, pharmaceutical developers, and CROs engaged in the development of next-generation therapeutics, including mRNA vaccines and protein replacement therapies. Our supply ensures consistent quality and reliability for these demanding applications.

Application

• mRNA Vaccine & Therapeutic Development: A key raw material for incorporating stabilizing modifications into synthetic mRNA constructs to improve efficacy and durability.
• Nucleic Acid Chemistry Research: Used in academic and industrial R&D for studying structure-activity relationships of modified nucleosides and their impact on RNA function.
• Bioconjugation & Probe Synthesis: The reactive amino and carboxyl groups enable site-specific labeling and conjugation for creating diagnostic probes or targeted drug delivery systems.
• Process Development & Scale-Up: Serves as a reference standard and starting material for process chemistry teams scaling up GMP-grade production of modified nucleotides.
• Antiviral & Anticancer Drug Discovery: Investigated as a precursor or analog in the search for novel nucleoside-based therapeutics that target viral replication or cellular proliferation.

Basic Information

Product Name	3-(3-Amino-3-Carboxypropyl)-1-Methylpseudouridine
CAS No.	52777-29-4
Molecular Formula	C11H17N3O7
Molecular Weight	303.27 g/mol
Synonyms	1-Methyl-3-(3-amino-3-carboxypropyl)pseudouridine; N1-Methyl-3-(3-amino-3-carboxypropyl)pseudouridine; 1-Methylpseudouridine-3-(3-aminopropanoic acid); m1ψ; 1-Methyl-ψ; Modified Nucleoside m1acp3ψ; (2S)-2-Amino-4-[[(1R,2R,3S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyl-2-oxocyclopentyl]amino]butanoic acid
EINECS	Contact for details

Quality Control

Every batch of 3-(3-Amino-3-Carboxypropyl)-1-Methylpseudouridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to support its use in critical research and development. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing identity, purity (HPLC), and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment and handled under conditions that minimize exposure to ambient light and humidity to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area%)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.