Description

Bunazosin Hydrochloride is a selective α-1 adrenergic receptor antagonist, a high-purity active pharmaceutical ingredient (API) of significant therapeutic importance. Its primary value lies in its potent antihypertensive and anti-glaucoma properties, making it a critical component in pharmaceutical formulations. This compound is essential for manufacturers in the pharmaceutical industry, particularly those developing and producing cardiovascular and ophthalmic medications.

Application

• Pharmaceutical API: Primary use as the active ingredient in antihypertensive drug formulations.
• Ophthalmic Solutions: Key component in medications for treating glaucoma by reducing intraocular pressure.
• Research & Development: Used as a reference standard and in pharmacological studies of α-adrenergic receptors.
• Finished Dosage Form Manufacturing: Incorporated into tablets, capsules, and injectable solutions.
• Contract Manufacturing: Supplied to CDMOs for the production of generic and branded pharmaceuticals.
• Veterinary Medicine: Potential application in veterinary pharmaceuticals for managing hypertension in animals.

Basic Information

Item	Detail
Product Name	Bunazosin Hydrochloride
CAS No.	52712-76-2
Molecular Formula	C19H27N5O4 · HCl
Molecular Weight	425.91 g/mol
Synonyms	Bunazosin HCl; 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]piperazine monohydrochloride; E-643; Detantol® (brand name); Bunazosin Hydrochloride Hydrate; α1-Adrenoceptor Antagonist Bunazosin; 4-Amino-2-[4-[(tetrahydro-2-furanylcarbonyl)-1-piperazinyl]-6,7-dimethoxyquinazoline Hydrochloride
EINECS	Contact for details

Quality Control

Our Bunazosin Hydrochloride is manufactured under strict quality management systems, ensuring it meets the rigorous standards required for pharmaceutical actives. Each batch is subjected to comprehensive analytical testing including identification, purity assay, and impurity profiling. A Certificate of Analysis (COA) is provided with every shipment, detailing results against specifications for identity, potency, and related substances. We support compliance with ICH guidelines and can supply material suitable for use in applications requiring GMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.