Description

1-(Trifluoroacetyl)-4β-[(Trimethylsilyl)Oxy]-L-Proline Trimethylsilyl Ester is a high-value, protected amino acid derivative that serves as a critical synthetic intermediate. Its core value proposition lies in enabling the precise construction of complex peptide and proline-based molecules under mild, controlled conditions. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel active pharmaceutical ingredients (APIs) and advanced protease inhibitors.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex peptide-based drugs and therapeutic agents.
• Protease Inhibitor Development: Used in research and production of inhibitors targeting specific enzymes like prolyl oligopeptidase.
• Peptide Chemistry: Facilitates the introduction of protected L-proline derivatives into peptide chains during solid-phase or solution-phase synthesis.
• Organic Synthesis: Serves as a versatile intermediate for constructing chiral, non-racemic compounds in medicinal chemistry programs.
• Bioconjugation: Potential use in creating labeled peptides or peptide-drug conjugates for diagnostic and therapeutic applications.
• Academic & Industrial R&D: A valuable reagent for investigating new synthetic methodologies and bioactive molecule libraries.

Basic Information

Product Name	1-(Trifluoroacetyl)-4β-[(Trimethylsilyl)Oxy]-L-Proline Trimethylsilyl Ester
CAS No.	52669-44-0
Molecular Formula	C13H22F3NO4Si2
Molecular Weight	369.48 g/mol
Synonyms	L-Proline, 1-(trifluoroacetyl)-4-(trimethylsiloxy)-, trimethylsilyl ester; 4-(Trimethylsiloxy)-1-(trifluoroacetyl)-L-proline trimethylsilyl ester; 1-(Trifluoroacetyl)-4-(trimethylsiloxy)-L-proline trimethylsilyl ester; 4β-(Trimethylsilyloxy)-1-(trifluoroacetyl)-L-proline trimethylsilyl ester; N-Trifluoroacetyl-4-trimethylsilyloxy-L-proline trimethylsilyl ester; TFA-4-TMS-Oxy-L-Proline TMS Ester; Protected L-Proline Derivative; (S)-1-((Trifluoroacetyl)-4-((trimethylsilyl)oxy)pyrrolidine-2-carboxylic acid trimethylsilyl ester
EINECS	Contact for details

Quality Control

Our 1-(Trifluoroacetyl)-4β-[(Trimethylsilyl)Oxy]-L-Proline Trimethylsilyl Ester is manufactured under controlled conditions to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to strict quality management protocols, and specifications can be aligned with customer requirements for advanced pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Optical Rotation	Contact for details
Water Content (KF)	< 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.