Description

Wyosine CAS NO 52662-10-9 is a naturally occurring, modified nucleoside found in transfer RNA (tRNA), specifically a hypermodified guanosine derivative. This compound is of significant interest in biochemical and pharmaceutical research due to its role in stabilizing tRNA structure and influencing translational fidelity. It serves as a critical reference standard and building block for researchers in nucleic acid chemistry, molecular biology, and drug discovery, particularly for studies involving tRNA modification, epigenetics, and the development of novel therapeutics.

Application

• Biochemical Research Standard: Used as a high-purity reference compound for the identification and quantification of wyosine and related modified nucleosides in biological samples via HPLC, LC-MS, or NMR.
• Nucleic Acid Chemistry: Serves as a specialized monomer or precursor for the chemical synthesis of modified oligonucleotides to study structure-function relationships in RNA.
• Enzymology Studies: Employed as a substrate or inhibitor to investigate the activity and mechanism of tRNA-modifying enzymes (e.g., tRNA methyltransferases).
• Pharmaceutical Development: Acts as a key intermediate in the research and development of novel antiviral or anticancer agents that target RNA modification pathways.
• Diagnostic Tool Development: Utilized in the creation of assays and kits to detect specific tRNA modifications linked to cellular stress, disease states, or metabolic disorders.

Basic Information

Product Name	Wyosine
CAS No.	52662-10-9
Molecular Formula	C₁₇H₂₃N₅O₇
Molecular Weight	409.40 g/mol
Synonyms	Y Nucleoside; 4,9-Dihydro-4,6-dimethyl-9-oxo-1H-imidazo[1,2-a]purine-7-butanoic acid, 1-β-D-ribofuranosyl-; 1-β-D-Ribofuranosyl-4,9-dihydro-4,6-dimethyl-9-oxo-1H-imidazo[1,2-a]purine-7-butanoic acid; Wybutosine nucleoside; tRNA Nucleoside Y; G+ Nucleoside
EINECS	Contact for details

Quality Control

Our Wyosine is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification, to ensure it meets the exacting standards required for advanced research. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation by atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.