Description

5-Chloro-Pyridin-2-Yl Isothiocyanate is a versatile heterocyclic building block characterized by its reactive isothiocyanate and chloro substituents. This compound is essential for the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research where precise molecular architecture is critical. It serves as a key intermediate for medicinal chemists and R&D professionals developing new active ingredients, offering a strategic handle for constructing thiazole, thiourea, and other sulfur-containing heterocycles.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging its heterocyclic core for bioactivity.
• Chemical Research & Development: Serves as a versatile scaffold in organic synthesis for constructing complex sulfur and nitrogen-containing heterocycles.
• Ligand and Chelating Agent Precursor: Utilized to create specialized ligands for catalysis and metal complexation studies.
• Material Science Applications: Potential building block for functionalized polymers and advanced organic materials.

Basic Information

Product Name	5-Chloro-Pyridin-2-Yl Isothiocyanate
CAS No.	52648-23-4
Molecular Formula	C6H3ClN2S
Molecular Weight	170.62 g/mol
Synonyms	2-Isothiocyanato-5-chloropyridine; 5-Chloro-2-pyridyl isothiocyanate; 5-Chloro-2-isothiocyanatopyridine; 5-Chloropyridine-2-isothiocyanate; 5-Chloro-2-pyridinyl isothiocyanate; (5-Chloro-2-pyridinyl)isothiocyanate; NSC 405124
EINECS	Contact for details

Quality Control

Our 5-Chloro-Pyridin-2-Yl Isothiocyanate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.