Description

4',5'-Didehydro-5'-Deoxycytidine is a chemically modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a crucial synthetic intermediate and a valuable scaffold for exploring novel therapeutic agents, particularly in the fields of antiviral and anticancer drug discovery. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of nucleotide-based active pharmaceutical ingredients (APIs) and prodrugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel nucleoside analog drugs targeting viral infections and cancer.
• Antiviral Research: Used as a precursor in the development of potential antiviral agents, including those targeting DNA and RNA viruses.
• Oncology Drug Discovery: Serves as a core structure for creating compounds that interfere with DNA synthesis and repair in cancer cells.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate nucleotide metabolism pathways.
• Prodrug Development: Utilized in the design of prodrugs to enhance the bioavailability and targeting of therapeutic nucleosides.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	4',5'-Didehydro-5'-Deoxycytidine
CAS No.	52523-42-9
Molecular Formula	C9H11N3O4
Molecular Weight	225.20 g/mol
Synonyms	5'-Deoxy-4',5'-didehydrocytidine; 2(1H)-Pyrimidinone, 4-amino-1-[5-(hydroxymethyl)-2-furanyl]-; 4-Amino-1-[5-(hydroxymethyl)-2-furanyl]-2(1H)-pyrimidinone; Cytidine, 5'-deoxy-4',5'-didehydro-; 4',5'-Didehydro-5'-deoxycytidine; 5'-Deoxy-4',5'-didehydrocytidine (VAN); 1-(5-(Hydroxymethyl)furan-2-yl)-4-aminopyrimidin-2(1H)-one
EINECS	Contact for details

Quality Control

Our 4',5'-Didehydro-5'-Deoxycytidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and impurities. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements. Specifications are designed to meet the high standards of pharmaceutical R&D and fine chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.