Description

5-Nitro-2,4-Bis-o-Trimethylsilyluracil is a key silylated nucleobase derivative, primarily used as a versatile building block and protective group intermediate in advanced organic synthesis. Its value lies in providing enhanced solubility and stability for sensitive uracil derivatives during complex chemical transformations. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of nucleoside analogs and other fine chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides that target specific biological pathways.
• Protective Group Chemistry: The trimethylsilyl (TMS) groups serve as protective agents for hydroxyl functions on the uracil ring during multi-step synthetic sequences.
• Organic Synthesis Building Block: Enables the introduction of a nitro-functionalized uracil core into more complex molecular architectures.
• Research & Development: A valuable reagent for academic and industrial R&D labs exploring modified nucleic acids and their biochemical properties.
• Material Science: Potential use in the creation of specialty polymers and functional materials with unique electronic properties.

Basic Information

Product Name	5-Nitro-2,4-Bis-o-Trimethylsilyluracil
CAS No.	52522-97-1
Molecular Formula	C12H23N3O4Si2
Molecular Weight	329.50 g/mol
Synonyms	2,4-Bis(trimethylsilyloxy)-5-nitropyrimidine; 5-Nitro-2,4-bis(trimethylsiloxy)uracil; 5-Nitrouracil-2,4-bis(trimethylsilyl) ether; 5-Nitrouracil bis(trimethylsilyl) derivative; 5-Nitro-2,4-bis-O-(trimethylsilyl)uracil; Uracil, 5-nitro-2,4-bis(trimethylsilyl)-; TMS-uracil nitro derivative
EINECS	Contact for details

Quality Control

Every batch of 5-Nitro-2,4-Bis-o-Trimethylsilyluracil is produced under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality management system is designed to meet the stringent requirements of research and fine chemical synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee reliable performance in your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.