Description

Furan-2-Carbonyl Chloride, Tetrahydro- CAS NO 52449-98-6 is a reactive acyl chloride derivative of tetrahydrofuran, serving as a versatile and critical building block in advanced organic synthesis. Its value lies in its ability to efficiently introduce the tetrahydrofuran-2-carbonyl moiety, enabling the construction of complex molecular architectures. This high-purity intermediate is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing tetrahydrofuran motifs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides requiring specific heterocyclic frameworks.
• Polymer Chemistry: Acts as a monomer or co-monomer for creating specialized polymers with unique thermal or mechanical properties.
• Ligand and Catalyst Development: Employed in the preparation of novel ligands and organocatalysts for asymmetric synthesis.
• Material Science Research: Facilitates the development of new organic materials and liquid crystals.
• Custom Synthesis and Contract Manufacturing: A crucial reagent for fine chemical manufacturers offering bespoke synthesis services.

Basic Information

Product Name	Furan-2-Carbonyl Chloride, Tetrahydro-
CAS No.	52449-98-6
Molecular Formula	C5H7ClO2
Molecular Weight	134.56 g/mol
Synonyms	Tetrahydrofuran-2-carbonyl chloride; 2-Tetrahydrofuroyl chloride; Dihydro-2-furoyl chloride; 2-Oxotetrahydrofuran-3-carbonyl chloride (tautomer); 2-Furoyl chloride, tetrahydro-; 3,4-Dihydro-2-furoyl chloride; 2-Tetrahydrofurancarboxylic acid chloride; α-Tetrahydrofuroyl chloride
EINECS	Contact for details

Quality Control

Our Furan-2-Carbonyl Chloride, Tetrahydro- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including assay by GC/HPLC, identity confirmation (IR, NMR), and impurity profiling, to ensure it meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area. Due to its hygroscopic and reactive acid chloride nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition. Recommended storage temperature: 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.