Description

5'-Cytidylic Acid, Monomethyl Ester (9Ci) is a chemically modified nucleotide derivative, specifically a monomethyl ester of cytidine 5'-monophosphate. This compound is a crucial building block and intermediate in the synthesis of more complex nucleosides, nucleotides, and oligonucleotides, offering precise control over molecular structure. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and life science sectors for applications in drug discovery, molecular biology, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used as a protected monomer or intermediate in the solid-phase synthesis of DNA and RNA oligonucleotides for research and diagnostic probes.
• Biochemical Research: Employed in enzymatic studies, metabolic pathway analysis, and as a substrate or inhibitor for nucleotide-processing enzymes.
• Prodrug Development: Acts as a modified nucleotide prodrug moiety to enhance cellular uptake and bioavailability of therapeutic agents.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for HPLC, LC-MS, or NMR method development and validation.

Basic Information

Item	Detail
Product Name	5'-Cytidylic Acid, Monomethyl Ester (9Ci)
CAS No.	52448-10-9
Molecular Formula	C11H16N3O8P
Molecular Weight	349.23 g/mol
Synonyms	Cytidine 5'-(methyl phosphate); 5'-O-Phosphonomethylcytidine; Cytidine 5'-monomethyl ester; Monomethyl cytidine 5'-phosphate; 5'-CMP methyl ester; 5'-Cytidine monophosphate methyl ester; Cytidylic acid monomethyl ester
EINECS	Contact for details

Quality Control

Every batch of 5'-Cytidylic Acid, Monomethyl Ester is produced and tested under stringent quality management protocols. We ensure compliance with relevant industry standards for research and pharmaceutical intermediates. Comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), is performed. A detailed Certificate of Analysis (COA) documenting batch-specific results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.