Description

5-Hydroxymethyl Xylouridine is a modified nucleoside derivative of significant interest in advanced biochemical research and development. This compound serves as a crucial building block and intermediate in the synthesis of novel oligonucleotides and nucleotide analogs. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, molecular biology, and the development of therapeutic nucleic acids. The high-purity material is essential for ensuring the fidelity and success of sensitive synthetic and biological applications.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for introducing modified bases into synthetic DNA/RNA strands for research and therapeutic applications.
• Antiviral Drug Development: Serves as a core scaffold or intermediate in the research of nucleoside analog prodrugs targeting viral polymerases.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to understand nucleic acid metabolism and repair mechanisms.
• Labeled Probe Development: Acts as a starting material for synthesizing fluorescently or radioactively labeled nucleotides for diagnostic assays and imaging.
• Medicinal Chemistry: A valuable intermediate for structure-activity relationship (SAR) studies aimed at optimizing the pharmacokinetic properties of nucleotide-based therapeutics.
• Academic Research: Employed in universities and institutes for fundamental studies in chemical biology, epigenetics, and nucleic acid chemistry.

Basic Information

Item	Details
Product Name	5-Hydroxymethyl Xylouridine
CAS No.	52448-09-6
Molecular Formula	C10H14N2O7
Molecular Weight	274.23 g/mol
Synonyms	5-(Hydroxymethyl)uridine, Xyloside; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione; 5-HMU; 5-Hydroxymethyl-2'-deoxyuridine analog; β-D-Xylofuranoside, 5-(hydroxymethyl)uridine
EINECS	Contact for details

Quality Control

Our 5-Hydroxymethyl Xylouridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., argon or nitrogen) for long-term storage to maintain stability and prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.