Description

6α-Chloro-5β-Hydroxywithaferin A is a specific, semi-synthetic derivative of the bioactive withanolide class, offering a modified pharmacological profile for advanced research and development. This compound is valued for its role as a key intermediate and reference standard in the exploration of novel therapeutic agents, particularly within anti-inflammatory and anti-cancer studies. It is primarily sought by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of high-purity fine chemicals for use in biochemical screening and synthetic chemistry programs.

Application

• Pharmaceutical Research & Development: Serves as a critical intermediate in the synthesis of novel withanolide-based drug candidates targeting inflammation and oncology.
• Biochemical Reference Standard: Used as a high-purity analytical standard for method development, validation, and quality control in laboratories studying withanolides.
• Mechanistic Studies: Employed in preclinical research to investigate structure-activity relationships (SAR) and specific biological pathways modulated by chlorinated withanolides.
• Natural Product Chemistry: Acts as a derivative for comparative analysis against natural withaferin A, helping to elucidate the impact of structural modifications on bioactivity.
• Fine Chemical Synthesis: Utilized as a building block for the custom synthesis of more complex, target-specific chemical entities for specialized client projects.

Basic Information

Product Name	6α-Chloro-5β-Hydroxywithaferin A
CAS No.	52329-20-1
Molecular Formula	C28H35ClO6
Molecular Weight	503.03 g/mol
Synonyms	6α-Chloro-5β-hydroxywithaferin A; 6α-Chloro-5β-hydroxywithaferin A (Withanolide E derivative); Chlorohydroxywithaferin A; Withaferin A, 6α-chloro-5β-hydroxy-; 6α-Chloro-5β,27-dihydroxy-1-oxo-22R-witha-2,24-dienolide
EINECS	Contact for details

Quality Control

Our 6α-Chloro-5β-Hydroxywithaferin A is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation and spectroscopic methods (NMR, MS) for structural verification, to ensure it meets the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) containing batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.