Description

5-Hydroxy-2'-Deoxycytidine is a modified nucleoside of significant research interest, featuring a hydroxyl group at the 5-position of the cytosine base. This structural modification makes it a critical compound for studying oxidative DNA damage, repair mechanisms, and epigenetic regulation. It is primarily utilized by research institutions and pharmaceutical companies engaged in genomics, molecular biology, and oncology research, as well as in the development of novel diagnostic and therapeutic agents.

Application

• Biomedical Research: A key biomarker and substrate for investigating oxidative stress-induced DNA damage and the base excision repair (BER) pathway.
• Epigenetics Studies: Used in research exploring the role of oxidized nucleosides in epigenetic modifications and gene expression.
• Analytical Standard: Serves as a high-purity reference standard in liquid chromatography-mass spectrometry (LC-MS) for quantifying DNA damage in biological samples.
• Pharmaceutical Development: Employed in the discovery and screening of drugs targeting DNA repair enzymes for cancer therapy.
• Diagnostic Kit Component: Utilized in the formulation of kits designed to detect and measure oxidative DNA damage for clinical and research diagnostics.

Basic Information

Product Name	5-Hydroxy-2'-Deoxycytidine
CAS No.	52278-77-0
Molecular Formula	C9H13N3O5
Molecular Weight	243.22 g/mol
Synonyms	5-OH-dC; 5-Hydroxy-2'-deoxycytidine; 5-Hydroxydeoxycytidine; 5-OH-2'-Deoxycytidine; 2'-Deoxy-5-hydroxycytidine; 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-hydroxycytosine; 5-Hydroxy-2'-deoxycytidine (5-OHdC)
EINECS	Contact for details

Quality Control

Our 5-Hydroxy-2'-Deoxycytidine is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.