Description

3'-(1-Butylphosphoryl)Adenosine is a chemically modified nucleoside derivative, specifically an adenosine analog with a butylphosphoryl group at the 3' position. This modification is crucial for its role as a key intermediate and building block in the synthesis of nucleotide-based pharmaceuticals and advanced biochemical research tools. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antiviral agents, nucleotide prodrugs, and novel therapeutic oligonucleotides.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of nucleotide analog prodrugs for antiviral and anticancer therapies.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving kinases and polymerases.
• Proteomics & Molecular Biology: Serves as a building block for labeling reagents and probes used in studying cellular signaling pathways.
• Antiviral Drug Development: Integral to the research and production of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral compounds.
• Chemical Biology Tool: Employed in the design and synthesis of activity-based probes to investigate nucleotide-binding proteins.

Basic Information

Product Name	3'-(1-Butylphosphoryl)Adenosine
CAS No.	52278-63-4
Molecular Formula	C14H22N5O7P
Molecular Weight	403.33 g/mol
Synonyms	Adenosine, 3'-(1-butylphosphoryl)-; 3'-O-(Butylphosphoryl)adenosine; 3'-Butylphosphoryl adenosine; 3'-Butylphosphoryl-9-β-D-ribofuranosyladenine; 9-β-D-Ribofuranosyladenine, 3'-(butylphosphoryl)-; Butylphosphoryl adenosine derivative; Nucleoside phosphonate intermediate
EINECS	Contact for details

Quality Control

Our 3'-(1-Butylphosphoryl)Adenosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for research and pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.