Description

Bicyclo[4.1.0]Heptane-7-Carbonyl Chloride, (1Alpha,6Alpha,7Alpha)- (9Ci) is a highly reactive bicyclic acid chloride derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in its rigid, strained bicyclic structure and defined stereochemistry, enabling the construction of complex molecular architectures with high precision. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for synthesizing novel active ingredients and complex natural product analogs.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and anti-infective drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where its bicyclic framework contributes to unique biological activity.
• Material Science Research: Serves as a precursor for specialty polymers and advanced organic materials requiring rigid, stereodefined monomers.
• Asymmetric Catalysis Ligand Precursor: Employed in the synthesis of novel chiral ligands and organocatalysts for stereoselective transformations.
• Natural Product & Fragrance Synthesis: A valuable building block for the total synthesis of complex natural products and high-value aroma chemicals.
• Chemical Biology & Proteomics: Can be utilized for the selective modification of biomolecules and the synthesis of activity-based probes.

Basic Information

Item	Details
Product Name	Bicyclo[4.1.0]Heptane-7-Carbonyl Chloride, (1Alpha,6Alpha,7Alpha)- (9Ci)
CAS No.	52163-17-4
Molecular Formula	C8H9ClO
Molecular Weight	156.61 g/mol
Synonyms	(1α,6α,7α)-Bicyclo[4.1.0]heptane-7-carbonyl chloride; 7-Carboxybicyclo[4.1.0]heptane, 7-chlorocarbonyl-, (1α,6α,7α)-; 1α,6α,7α-Bicyclo[4.1.0]heptane-7-carbonyl chloride; 7-Norcaranyl carbonyl chloride; (1R,6R,7R)-Bicyclo[4.1.0]heptane-7-carbonyl chloride (enantiomer); Bicyclo[4.1.0]heptane-7-carbonyl chloride, (1R,6R,7R)-rel-; 7-Chlorocarbonylbicyclo[4.1.0]heptane
EINECS	Contact for details

Quality Control

Every batch of Bicyclo[4.1.0]Heptane-7-Carbonyl Chloride undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocols are designed to meet the stringent requirements of research and development as well as cGMP standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity (typically by GC or HPLC), chiral purity, and impurity profiles is provided with each shipment to guarantee reliable performance in your critical synthetic steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and moisture-sensitive nature, containers should be kept under an inert atmosphere (e.g., nitrogen or argon) after opening. Recommended long-term storage temperature is 2-8°C. Keep away from strong bases, alcohols, and moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Chiral Purity (Chiral GC/HPLC)	≥ 98.0% ee
Water Content (Karl Fischer)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.