Description

2-Quinolinecarbonyl Chloride,4-Chloro is a versatile and highly reactive chlorinated quinoline derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to introduce the 4-chloroquinoline-2-carbonyl moiety, a key structural motif for developing compounds with targeted biological activity. This intermediate is essential for research and production chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for antimalarial and anticancer drug candidates.
• Agrochemical Synthesis: Building block for developing new generation herbicides, fungicides, and insecticides with the quinoline scaffold.
• Material Science Research: Used in the creation of organic ligands, metal-organic frameworks (MOFs), and functional polymers.
• Dye and Pigment Manufacturing: Intermediate for synthesizing complex heterocyclic dyes and optical brighteners.
• Academic & R&D: A valuable reagent for medicinal chemistry research and method development in organic synthesis laboratories.

Basic Information

Product Name	2-Quinolinecarbonyl Chloride,4-Chloro
CAS No.	52144-09-9
Molecular Formula	C₁₀H₅Cl₂NO
Molecular Weight	226.06 g/mol
Synonyms	4-Chloroquinoline-2-carbonyl chloride; 4-Chloro-2-quinolinecarbonyl chloride; 4-Chloro-quinoline-2-carboxylic acid chloride; 2-Carbamoyl-4-chloroquinoline; 4-Chloro-2-quinolinecarboxylic acid chloride
EINECS	Contact for details

Quality Control

Every batch of 2-Quinolinecarbonyl Chloride,4-Chloro is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency meet the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and reactive acid chloride nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.