Description

6-Morpholino-3-Pyridinyl Isothiocyanate is a versatile heterocyclic building block and reagent of significant interest in advanced organic synthesis. Its core value lies in its bifunctional structure, combining a morpholino-substituted pyridine ring with a reactive isothiocyanate group, enabling its use in the construction of complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and other targeted therapy research.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents and herbicides.
• Ligand and Chelator Precursor: Serves as a starting material for synthesizing specialized ligands used in catalysis and metal complexation studies.
• Polymer Modification: The isothiocyanate group can react with amines to introduce functional pyridine-morpholine units into polymer chains for specialty materials.
• Bioconjugation Chemistry: Employed in research for labeling biomolecules (proteins, peptides) due to the reactivity of the isothiocyanate group with amine functionalities.
• Chemical Biology Probes: Useful in designing activity-based probes and other tools for investigating biological pathways and enzyme functions.

Basic Information

Product Name	6-Morpholino-3-Pyridinyl Isothiocyanate
CAS No.	52024-29-0
Molecular Formula	C10H11N3OS
Molecular Weight	221.28 g/mol
Synonyms	3-Isothiocyanato-6-morpholinopyridine; 6-Morpholinopyridin-3-yl isothiocyanate; 3-Pyridinol, 6-morpholino-, isothiocyanate; 6-Morpholino-3-pyridyl isothiocyanate; 52024-29-0; 6-Morpholin-3-pyridinyl isothiocyanate; 3-Isothiocyanato-6-(4-morpholinyl)pyridine
EINECS	Contact for details

Quality Control

Our 6-Morpholino-3-Pyridinyl Isothiocyanate is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.