Description

4-Isothiocyanatobenzene-1-Sulfonamide is a specialized aromatic sulfonamide derivative featuring a reactive isothiocyanate functional group. This compound is a valuable synthetic intermediate, prized for its ability to serve as a versatile building block in the creation of more complex molecules. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and biochemical probes.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in the development of enzyme inhibitors and receptor modulators.
• Agrochemical Research: Used in the creation of novel herbicides, fungicides, and pesticides by acting as a core structure for active ingredient development.
• Bioconjugation & Probe Synthesis: The reactive isothiocyanate group enables covalent attachment to amines in proteins, peptides, or other biomolecules, useful for creating fluorescent probes, affinity labels, and diagnostic reagents.
• Material Science: Serves as a monomer or cross-linking agent in the synthesis of specialized polymers with unique thermal or chemical properties.
• Chemical Biology: Employed in activity-based protein profiling (ABPP) and other chemoproteomic approaches to study enzyme function and discover new biological targets.

Basic Information

Product Name	4-Isothiocyanatobenzene-1-Sulfonamide
CAS No.	51908-29-3
Molecular Formula	C7H6N2O2S2
Molecular Weight	214.26 g/mol
Synonyms	4-Isothiocyanatobenzenesulfonamide; p-Isothiocyanatobenzenesulfonamide; Benzenesulfonamide, 4-isothiocyanato-; 1-Isothiocyanato-4-sulfamoylbenzene; NSC 403914; 4-Sulfamoylphenyl isothiocyanate
EINECS	Contact for details

Quality Control

Our 4-Isothiocyanatobenzene-1-Sulfonamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.