Description

Diethyl Bromophosphate is a versatile organophosphorus reagent primarily used as a phosphorylating and brominating agent in organic synthesis. Its high reactivity makes it a critical intermediate for constructing complex molecules in advanced research and industrial chemical production. This compound is essential for manufacturers and R&D laboratories in the pharmaceutical, agrochemical, and specialty chemical sectors seeking efficient synthetic pathways.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for nucleotide analogs and antiviral/anticancer agents.
• Agrochemical Synthesis: Used in the production of organophosphate-based pesticides, herbicides, and plant growth regulators.
• Chemical Reagent: Acts as a phosphorylating agent for alcohols and phenols, and as a source of bromine in halogenation reactions.
• Flame Retardant Precursor: Intermediate in the manufacture of specialized organophosphate flame retardants for polymers and textiles.
• Ligand and Catalyst Preparation: Employed in the synthesis of phosphonate ligands for metal complexes and catalysts.
• Polymer Modification: Used to introduce phosphate or bromine functional groups into polymer chains to alter material properties.

Basic Information

Product Name	Diethyl Bromophosphate
CAS No.	51761-27-4
Molecular Formula	C4H10BrO3P
Molecular Weight	217.00 g/mol
Synonyms	Bromophosphoric Acid Diethyl Ester; Diethoxyphosphoryl Bromide; Diethyl Phosphorobromidate; Phosphorobromidic Acid, Diethyl Ester; O,O-Diethyl Phosphorobromidate; Ethyl Bromophosphate; NSC 84466
EINECS	257-386-5

Quality Control

Our Diethyl Bromophosphate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality system adheres to cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Density (20°C)	~1.45 g/cm³
Refractive Index (n20D)	~1.445

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.