Description

5-Methyl-2-Phenyl-1,3-Oxazole-4-Carbonyl Chloride is a high-purity, reactive acyl chloride derivative of a substituted oxazole, serving as a critical building block in advanced organic synthesis. Its value lies in enabling the efficient introduction of the 5-methyl-2-phenyloxazole-4-carbonyl moiety, a privileged scaffold in medicinal chemistry, into target molecules. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that incorporate the oxazole heterocycle.
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and advanced polymers with specific electronic or optical properties.
• Peptide Mimetics & Bioconjugation: Facilitates the creation of oxazole-based peptide analogs and the labeling of biomolecules for diagnostic or research purposes.
• Chemical Biology Probes: Serves as a precursor for activity-based probes and other tools used to study enzyme function and biological pathways.

Basic Information

Product Name	5-Methyl-2-Phenyl-1,3-Oxazole-4-Carbonyl Chloride
CAS No.	51655-71-1
Molecular Formula	C11H8ClNO2
Molecular Weight	221.64 g/mol
Synonyms	5-Methyl-2-phenyloxazole-4-carbonyl chloride; 4-Oxazolecarbonyl chloride, 5-methyl-2-phenyl-; 2-Phenyl-5-methyl-4-oxazolecarbonyl chloride; 5-Methyl-2-phenyl-1,3-oxazole-4-carboxylic acid chloride; 5-Methyl-2-phenyloxazole-4-carboxylic acid chloride; 5-Methyl-2-phenyl-4-oxazolecarbonyl chloride
EINECS	Contact for details

Quality Control

Our 5-Methyl-2-Phenyl-1,3-Oxazole-4-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting cGMP (current Good Manufacturing Practice) requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in common organic solvents (e.g., DCM, THF, DMF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.