Description

(Dimethylamino)Acetyl Chloride CAS NO 51552-16-0 is a versatile and highly reactive acyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to efficiently introduce the (dimethylamino)acetyl moiety, a key functional group for modulating the physicochemical and biological properties of target molecules. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring amino acid derivatives or peptide mimetics.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides where the dimethylamino group enhances bioavailability or activity.
• Peptide Coupling Agent: Functions as an acylating agent for the introduction of protected amino groups in solid-phase and solution-phase peptide synthesis.
• Dye and Pigment Manufacturing: Intermediate in the synthesis of specialized dyes and pigments, contributing to color fastness and solubility properties.
• Polymer Modification: Employed to functionalize polymers, introducing reactive sites or altering surface properties for advanced material applications.
• Ligand and Catalyst Preparation: Building block for creating complex ligands and organocatalysts used in asymmetric synthesis.
• Research & Development: A valuable tool in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	(Dimethylamino)Acetyl Chloride
CAS No.	51552-16-0
Molecular Formula	C4H8ClNO
Molecular Weight	121.56 g/mol
Synonyms	2-(Dimethylamino)acetyl chloride; N,N-Dimethylglycyl chloride; DMAC; Chloroacetyl dimethylamine; Acetyl chloride, 2-(dimethylamino)-; (Dimethylamino)ethanoyl chloride; N,N-Dimethyl-2-chloroacetamide (tautomeric form); Glycine, N,N-dimethyl-, chloride
EINECS	257-250-1

Quality Control

Our (Dimethylamino)Acetyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including assay by titration and impurity profiling by gas chromatography (GC) or HPLC, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurity limits is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at temperatures between 2°C and 8°C (refrigerated) to maximize stability. This product is hygroscopic (moisture-sensitive) and reacts vigorously with water, strong bases, and alcohols. Containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture and to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/Titration)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Report and comply with agreed limits
Density	~1.09 g/cm³ at 20°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.