Description

3'-o-Acetyl-2'-Deoxyguanosine is a chemically modified nucleoside derivative, serving as a crucial building block and protective group intermediate in oligonucleotide synthesis. This compound matters for its role in enabling the precise construction of DNA sequences, particularly in the development of primers, probes, and therapeutic nucleic acids. It is primarily needed by research institutions, pharmaceutical developers, and biotechnology companies engaged in molecular biology, genomics, and the production of advanced therapeutics.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of DNA strands, used in primers and probes.
• Antiviral & Anticancer Drug Research: Serves as an intermediate in the development of nucleoside analog prodrugs targeting viral replication and cancer cell proliferation.
• Biochemical Research: Used in enzymatic studies and as a substrate to investigate nucleotide metabolism and related pathways.
• Diagnostic Reagent Manufacturing: Incorporated into the production of labeled nucleotides for various detection and diagnostic assays.
• Protective Group Chemistry: The acetyl group at the 3'-position provides selective protection during complex multi-step synthetic sequences.

Basic Information

Product Name	3'-o-Acetyl-2'-Deoxyguanosine
CAS No.	51549-58-7
Molecular Formula	C12H15N5O5
Molecular Weight	309.28 g/mol
Synonyms	2'-Deoxyguanosine 3'-acetate; 3'-O-Acetyl-2'-deoxyguanosine; 9-[(2R,5R)-5-(Acetyloxymethyl)-3,4-dihydroxyoxolan-2-yl]-6,9-dihydro-1H-purin-6-one; 2'-Deoxy-3'-O-acetylguanosine; dG(Ac); Guanosine, 2'-deoxy-, 3'-acetate
EINECS	Contact for details

Quality Control

Our 3'-o-Acetyl-2'-Deoxyguanosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.