Description

N6,3'-o-Dibenzoyl-2'-Deoxyadenosine is a key protected nucleoside derivative, specifically designed for advanced oligonucleotide synthesis and pharmaceutical research. This compound is critical for ensuring high coupling efficiency and regioselectivity during the automated synthesis of DNA sequences and antisense oligonucleotides. It is an essential building block for research institutions, pharmaceutical developers, and CROs engaged in the development of novel therapeutics, diagnostics, and molecular biology tools.

Application

• Solid-Phase Oligonucleotide Synthesis: Serves as a protected phosphoramidite precursor for the automated synthesis of DNA strands.
• Antisense & siRNA Drug Development: A crucial raw material in the research and production of therapeutic oligonucleotides targeting specific genes.
• Molecular Biology Research: Used in the study of nucleic acid structure, function, and for creating custom probes and primers.
• Pharmaceutical Intermediates: Acts as a key synthetic intermediate in the preparation of nucleoside-based antiviral or anticancer agents.
• Diagnostic Reagent Manufacturing: Employed in the production of labeled nucleotides for diagnostic assays and sequencing technologies.

Basic Information

Product Name	N6,3'-o-Dibenzoyl-2'-Deoxyadenosine
CAS No.	51549-54-3
Molecular Formula	C25H23N5O5
Molecular Weight	473.48 g/mol
Synonyms	2'-Deoxy-N6,3'-O-dibenzoyladenosine; 2'-Deoxyadenosine, N6,3'-bis(benzoyl)-; N6,3'-Di-O-benzoyl-2'-deoxyadenosine; 3'-O-Benzoyl-N6-benzoyl-2'-deoxyadenosine; N6-Benzoyl-3'-O-benzoyl-2'-deoxyadenosine; Protected 2'-Deoxyadenosine Derivative; dA(Bz) Bz Precursor
EINECS	Contact for details

Quality Control

Every batch of N6,3'-o-Dibenzoyl-2'-Deoxyadenosine is manufactured and tested under strict quality management systems to ensure it meets the exacting standards required for sensitive synthetic applications. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to guarantee identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.