Description

N4,3'-o-Dibenzoyl-2'-Deoxycytidine is a key protected nucleoside derivative, specifically designed for advanced oligonucleotide synthesis and pharmaceutical research. This compound is critical for ensuring high coupling efficiency and regioselectivity during the automated synthesis of DNA sequences and antisense oligonucleotides. It is an essential building block for researchers and manufacturers in the fields of therapeutic development, molecular diagnostics, and biochemical research, where precise and reliable nucleotide chemistry is paramount.

Application

• Solid-Phase Oligonucleotide Synthesis: Serves as a protected phosphoramidite precursor for the automated assembly of DNA strands.
• Antisense & siRNA Therapeutics: A crucial raw material in the production of modified oligonucleotides for gene silencing applications.
• Pharmaceutical Intermediate: Used in the research and development of nucleoside-based antiviral and anticancer drugs.
• Molecular Biology Research: Employed in the synthesis of probes, primers, and other custom DNA sequences for diagnostic and research purposes.
• Bioconjugation Chemistry: Acts as a starting material for creating labeled nucleotides or nucleotide-protein conjugates.
• Process Development & Scale-Up: Supports the transition from laboratory-scale research to commercial manufacturing of oligonucleotide APIs.

Basic Information

Product Name	N4,3'-o-Dibenzoyl-2'-Deoxycytidine
CAS No.	51549-49-6
Molecular Formula	C24H21N3O6
Molecular Weight	447.44 g/mol
Synonyms	2'-Deoxycytidine, N4,3'-bis(benzoyl)-; 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-4-N,3-O-bis(benzoyl)cytosine; N4,3'-Di-O-benzoyl-2'-deoxycytidine; N4,3'-O-Dibenzoyl-deoxycytidine; 3',N4-Dibenzoyl-2'-deoxycytidine; N4,3'-O-Dibenzoyldeoxycytidine; dC(Bz)2; Protected 2'-Deoxycytidine
EINECS	Contact for details

Quality Control

Our N4,3'-o-Dibenzoyl-2'-Deoxycytidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical and biotech applications. A comprehensive Certificate of Analysis (COA) detailing purity, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.