Description

Adenosine,n-Benzoyl-2'-Deoxy-3'-o-[(1,1-Dimethylethyl)Dimethylsilyl]- CAS NO 51549-40-7 is a key protected nucleoside derivative, specifically designed for advanced oligonucleotide synthesis. This compound matters as a critical building block, offering precise control over nucleic acid structure and function for research and therapeutic development. It is essential for pharmaceutical R&D teams, diagnostic developers, and academic institutions engaged in the synthesis of modified DNA/RNA sequences, antisense oligonucleotides, and other nucleic acid-based technologies.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Oligonucleotide Synthesis: Used as a protected phosphoramidite monomer in solid-phase synthesis for research-scale and GMP-grade oligonucleotide production.
• Antisense Technology: A fundamental component for creating antisense oligonucleotides (ASOs) that modulate gene expression.
• siRNA and miRNA Research: Employed in the development and manufacture of small interfering RNA (siRNA) and microRNA (miRNA) constructs for therapeutic and research applications.
• Diagnostic Probe Development: Integral for creating labeled and modified DNA probes used in PCR, sequencing, and microarray technologies.
• Bioconjugation and Labeling: Provides a reactive handle for attaching fluorophores, quenchers, or other functional groups to nucleic acids.
• Academic & Industrial R&D: Supports fundamental research in biochemistry, molecular biology, and medicinal chemistry exploring nucleic acid structure and function.

Basic Information

Product Name	Adenosine,n-Benzoyl-2'-Deoxy-3'-o-[(1,1-Dimethylethyl)Dimethylsilyl]-
CAS No.	51549-40-7
Molecular Formula	C23H31N5O4Si
Molecular Weight	469.62 g/mol
Synonyms	5'-O-DMT-2'-Deoxy-N6-Benzoyladenosine-3'-O-TBDMS; N6-Benzoyl-2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]adenosine; 2'-Deoxy-N6-benzoyladenosine 3'-(tert-butyldimethylsilyl) ether; 3'-O-TBDMS-N6-Bz-2'-deoxyadenosine; dA(Bz)-3'-O-TBDMS; Protected 2'-Deoxyadenosine Derivative; N6-Benzoyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxyadenosine
EINECS	Contact for details

Quality Control

Our Adenosine,n-Benzoyl-2'-Deoxy-3'-o-[(1,1-Dimethylethyl)Dimethylsilyl]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity suitable for sensitive oligonucleotide synthesis. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.