Description

N6-Benzoyl-5'-o-tert-Butyldimethylsilyl-2'-Deoxyadenosine is a key protected nucleoside derivative, specifically designed for advanced oligonucleotide synthesis. This compound is critical for researchers and manufacturers requiring high-purity, chemically modified building blocks for the production of DNA/RNA analogs, antisense oligonucleotides, and primers. It is essential for pharmaceutical R&D, diagnostic assay development, and academic research in molecular biology and medicinal chemistry.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): Serves as a crucial phosphoramidite precursor for the automated synthesis of modified DNA strands.
• Antisense & siRNA Therapeutic Development: Used in the research and production of therapeutic oligonucleotides targeting specific genes.
• Primer & Probe Manufacturing: Enables the creation of specialized primers and fluorescent probes for PCR and diagnostic applications.
• Medicinal Chemistry & Drug Discovery: Acts as a scaffold for developing nucleoside-based antiviral and anticancer agents.
• Academic & Industrial R&D: A fundamental reagent for studying nucleic acid structure, function, and stability.

Basic Information

Product Name	N6-Benzoyl-5'-o-tert-Butyldimethylsilyl-2'-Deoxyadenosine
CAS No.	51549-39-4
Molecular Formula	C25H35N5O4Si
Molecular Weight	497.67 g/mol
Synonyms	2'-Deoxy-N6-benzoyl-5'-O-(tert-butyldimethylsilyl)adenosine; 5'-O-(tert-Butyldimethylsilyl)-N6-benzoyl-2'-deoxyadenosine; N6-Bz-5'-O-TBDMS-dA; Bz-dA(TBDMS); N6-Benzoyl-5'-O-TBDMS-2'-deoxyadenosine; 2'-Deoxyadenosine, N6-benzoyl-5'-O-(1,1-dimethylethyl)dimethylsilyl-; Protected 2'-Deoxyadenosine Derivative
EINECS	Contact for details

Quality Control

Our N6-Benzoyl-5'-o-tert-Butyldimethylsilyl-2'-Deoxyadenosine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are supported by comprehensive analytical data, including HPLC, 1H/13C NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.