Description

N4-Benzoyl-5'-o-tert-Butyldimethylsilyl-2'-Deoxycytidine is a key protected nucleoside derivative, essential for the controlled synthesis of oligonucleotides. This compound is specifically designed to offer superior stability and selectivity during complex chemical coupling reactions, ensuring high yields and purity in the final product. It is a critical building block for researchers and manufacturers in pharmaceutical development, diagnostic probe synthesis, and advanced antisense oligonucleotide production.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): A crucial phosphoramidite precursor for the automated synthesis of DNA and RNA sequences.
• Antisense and siRNA Therapeutics: Used in the research and GMP-scale production of therapeutic oligonucleotides targeting genetic diseases.
• Diagnostic Probe Manufacturing: Enables the creation of labeled probes for PCR, FISH, and microarray technologies.
• Medicinal Chemistry & Drug Discovery: Serves as a protected intermediate in the development of nucleoside-based antiviral and anticancer agents.
• Academic & Industrial Research: A fundamental reagent for studying nucleic acid chemistry, enzyme mechanisms, and developing novel bioconjugation methods.

Basic Information

Product Name	N4-Benzoyl-5'-o-tert-Butyldimethylsilyl-2'-Deoxycytidine
CAS No.	51549-36-1
Molecular Formula	C22H31N3O5Si
Molecular Weight	445.59 g/mol
Synonyms	5'-O-(tert-Butyldimethylsilyl)-N4-benzoyl-2'-deoxycytidine; N4-Benzoyl-5'-O-TBDMS-2'-deoxycytidine; 2'-Deoxycytidine, N4-benzoyl-5'-O-[1,1-dimethylethyl)dimethylsilyl]-; dC(Bz) TBDMS; N4-Bz-5'-O-TBDMS-dC; Protected 2'-Deoxycytidine; TBDMS-dC(Bz)
EINECS	Contact for details

Quality Control

Our production of this high-value nucleoside intermediate adheres to stringent quality protocols. Every batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality system is designed to support GMP-for-intermediate applications and rigorous research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.