Description

5'-O-TBDMS-2'-Deoxyguanosine is a key protected nucleoside derivative, essential for the controlled synthesis of oligonucleotides. This compound matters because it provides a critical building block for research and development in nucleic acid chemistry, enabling the creation of modified DNA sequences. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic laboratories focused on antisense therapeutics, diagnostic probes, and synthetic biology.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): A fundamental phosphoramidite precursor for the automated synthesis of DNA and RNA strands.
• Antisense and siRNA Drug Development: Used in the research and production of therapeutic oligonucleotides targeting specific genes.
• Diagnostic Probe Fabrication: Essential for creating labeled probes used in PCR, sequencing, and microarray technologies.
• Synthetic Biology and Genetic Engineering: Serves as a modified nucleotide for constructing artificial genes and studying nucleic acid function.
• Academic and Industrial Research: A vital reagent for chemical biology studies exploring DNA structure, replication, and repair mechanisms.

Basic Information

Product Name	5'-O-TBDMS-2'-Deoxyguanosine
CAS No.	51549-33-8
Molecular Formula	C18H31N5O4Si
Molecular Weight	409.56 g/mol
Synonyms	2'-Deoxyguanosine, 5'-O-[(1,1-Dimethylethyl)dimethylsilyl]-; 5'-O-(tert-Butyldimethylsilyl)-2'-deoxyguanosine; 5'-O-TBDMS-dG; Guanosine, 2'-deoxy-, 5'-(tert-butyldimethylsilyl) ether; 51549-33-8; TBDMS-protected deoxyguanosine; 2'-Deoxy-5'-O-(tert-butyldimethylsilyl)guanosine
EINECS	Contact for details

Quality Control

Our 5'-O-TBDMS-2'-Deoxyguanosine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in common organic solvents (e.g., DMF, DMSO, acetonitrile)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.