Description

Cimetidine CAS NO 51481-61-9 is a histamine H₂-receptor antagonist that effectively inhibits gastric acid secretion. This makes it a critical active pharmaceutical ingredient (API) for the formulation of medications targeting acid-related gastrointestinal disorders. It is primarily required by pharmaceutical manufacturers for the production of anti-ulcer and gastroesophageal reflux disease (GERD) treatments, as well as by research institutions for biochemical studies.

Application

• Primary use as an Active Pharmaceutical Ingredient (API) in the manufacture of prescription and over-the-counter anti-ulcer medications.
• Formulation of drugs for the treatment of gastroesophageal reflux disease (GERD) and Zollinger-Ellison syndrome.
• Key intermediate in advanced pharmaceutical synthesis and research chemical for studying histamine pathways.
• Reference standard in analytical laboratories for quality control and method development (HPLC, spectroscopy).
• Used in veterinary pharmaceuticals for managing gastric conditions in animals.

Basic Information

Product Name	Cimetidine
CAS No.	51481-61-9
Molecular Formula	C10H16N6S
Molecular Weight	252.34 g/mol
Synonyms	N"-Cyano-N-methyl-N'-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine; SKF 92334; Cimetidin; Tagamet; Cimetidine Base; 1-Cyano-2-methyl-3-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine
EINECS	257-234-2

Quality Control

Our Cimetidine is produced under GMP-guided conditions, ensuring it meets stringent pharmacopeial standards for pharmaceutical use. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure compliance with major global standards, including USP, EP, and BP monographs, and can provide documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to protect from moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Microbial Enumeration	Meets EP/USP criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.