Description

2,2'-Anhydro-1-(3'-o-Acetyl-β-Arabinofuranosyl)-5-Iodocytosine is a key nucleoside analog intermediate of significant interest in advanced pharmaceutical research and development. Its primary value lies in its role as a sophisticated building block for the synthesis of novel antiviral and anticancer agents, particularly within the field of modified oligonucleotides. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require reliable, high-quality intermediates for complex synthetic pathways.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel nucleoside-based antiviral and anticancer drugs.
• Antiviral Drug Research: Used in the development of therapeutic agents targeting viral infections, leveraging its modified cytosine structure.
• Oligonucleotide Synthesis: Serves as a specialized building block for creating modified DNA or RNA strands for therapeutic and diagnostic applications.
• Biochemical Research: Employed in studies investigating nucleoside metabolism, enzyme inhibition, and mechanism of action for new drug candidates.
• Prodrug Development: The acetyl-protected arabinofuranosyl moiety makes it a valuable intermediate for designing prodrugs with improved bioavailability.
• Medicinal Chemistry: A versatile scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of drug molecules.

Basic Information

Product Name	2,2'-Anhydro-1-(3'-o-Acetyl-β-Arabinofuranosyl)-5-Iodocytosine
CAS No.	51391-98-1
Molecular Formula	C11H12IN3O5
Molecular Weight	393.14 g/mol
Synonyms	5-Iodo-1-(3-O-acetyl-2,5-anhydro-β-D-arabinofuranosyl)cytosine; 1-(3-O-Acetyl-2,5-anhydro-β-D-arabinofuranosyl)-5-iodocytosine; 2,2'-Anhydro-1-(3-O-acetyl-β-D-arabinofuranosyl)-5-iodocytosine; 5-Iodocytosine arabinoside 3'-acetate 2,2'-anhydro derivative; β-D-Arabinofuranoside, 1-(3-O-acetyl-2,5-anhydro-5-iodocytosin-1-yl)-; AIAC (common abbreviation)
EINECS	Contact for details

Quality Control

Our 2,2'-Anhydro-1-(3'-o-Acetyl-β-Arabinofuranosyl)-5-Iodocytosine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for research and pharmaceutical applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.