Description

Tiamenidine Hydrochloride is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) with significant therapeutic relevance. Its primary value lies in its role as a key synthetic component for the development of centrally-acting α-2 adrenergic agonists, which are critical in neurological and cardiovascular research. This compound is essential for pharmaceutical manufacturers, R&D laboratories, and academic institutions engaged in the synthesis of novel therapeutic agents and the study of receptor pharmacology.

Application

• Pharmaceutical API Synthesis: Primary use as an active pharmaceutical ingredient or a critical intermediate in the production of centrally-acting antihypertensive and neurological medications.
• Neurological Research: Used in preclinical and clinical research to study α-2 adrenergic receptor mechanisms, pain modulation, and spasticity management.
• Cardiovascular Drug Development: Serves as a key building block in the R&D of drugs targeting blood pressure regulation and sympathetic nervous system activity.
• Reference Standard: Employed as a high-purity analytical reference standard in quality control (QC) and quality assurance (QA) laboratories for method development and validation.
• Academic & Contract Research: Utilized by universities and CROs (Contract Research Organizations) for pharmacological studies and synthetic chemistry projects.
• Process Chemistry & Scale-Up: Integral to process development and optimization for the commercial-scale manufacturing of finished dosage forms.

Basic Information

Product Name	Tiamenidine Hydrochloride
CAS No.	51274-83-0
Molecular Formula	C9H15Cl2N3S
Molecular Weight	268.21 g/mol
Synonyms	2-[(1,3-Benzothiazol-2-yl)imino]imidazolidine Hydrochloride; Tiamenidine HCl; 2-[(2-Benzothiazolyl)imino]imidazolidine Monohydrochloride; Tiamenidin Hydrochloride; B-HT 920 Hydrochloride; BHT 920; BHT-920; BHT920
EINECS	Contact for details

Quality Control

Our Tiamenidine Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability. The product undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to meet stringent pharmaceutical-grade specifications. A Certificate of Analysis (COA) detailing all test results is provided with each batch to support your regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.