Description

(9R,10S,17R)-19-Norpregna-4-Ene-20-Yne-17-Ol is a high-purity steroidal intermediate of significant importance in pharmaceutical synthesis. This compound matters for its role as a key chiral building block in the production of advanced active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, biotechnology, and advanced organic synthesis sectors for developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of steroidal drugs and hormone-based therapies.
• Research & Development: Used in academic and industrial R&D for exploring new synthetic pathways and novel bioactive compounds.
• Fine Chemical Synthesis: Serves as a specialized building block for creating complex organic molecules with high stereochemical purity.
• API Manufacturing: Integral in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) requiring specific stereochemistry.
• Reference Standard: Employed as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(9R,10S,17R)-19-Norpregna-4-Ene-20-Yne-17-Ol
CAS No.	51269-18-2
Molecular Formula	C₂₀H₂₈O
Molecular Weight	284.44 g/mol
Synonyms	19-Norpregna-4-ene-20-yne-17-ol, (9R,10S,17R)-; 17β-Hydroxy-19-norpregna-4-en-20-yne; 19-Nor-17α-pregna-4-en-20-yn-17-ol; Tibolone intermediate; Livial intermediate; Steroid 51269-18-2; Org OD-14 intermediate; (8R,9S,13R,14S)-13-ethyl-17-ethynyl-3-hydroxy-1,2,6,7,8,9,10,11,12,13,14,15-dodecahydrocyclopenta[a]phenanthren-17-ol
EINECS	Contact for details

Quality Control

Our (9R,10S,17R)-19-Norpregna-4-Ene-20-Yne-17-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the high standards required for pharmaceutical intermediates. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.