Description

8-(4-Chlorophenylthio)Guanosine 3',5'-Cyclic Monophosphate Sodium Salt is a chemically modified, cell-permeable analog of cyclic GMP (cGMP) designed for research applications. This compound is a valuable tool for studying intracellular signaling pathways, particularly those mediated by cGMP-dependent protein kinases (PKG) and cyclic nucleotide-gated ion channels. It is primarily utilized by researchers and scientists in the fields of pharmacology, molecular biology, and biochemistry for investigating cellular processes, drug discovery, and signal transduction mechanisms.

Application

• Biochemical Research: A key reagent for studying the role of cGMP as a second messenger in cellular signaling cascades.
• Pharmacology & Drug Discovery: Used in high-throughput screening assays to identify and characterize novel modulators of PKG and phosphodiesterase (PDE) activity.
• Cardiovascular & Neurobiology Studies: Investigates cGMP-mediated effects on vascular smooth muscle relaxation, platelet aggregation, and neuronal function.
• Cell Biology: Employed to probe intracellular pathways involved in cell growth, differentiation, and apoptosis.
• Enzyme Kinetics: Serves as a substrate or activator in enzymatic studies of guanylyl cyclases and phosphodiesterases.
• Academic & Institutional Research: A standard research chemical for universities and R&D institutions focused on signal transduction.

Basic Information

Product Name	8-(4-Chlorophenylthio)Guanosine 3',5'-Cyclic Monophosphate Sodium Salt
CAS No.	51239-26-0
Molecular Formula	C17H15ClN5O7PS•Na
Molecular Weight	529.75 g/mol
Synonyms	8-pCPT-cGMP Sodium Salt; 8-(4-Chlorophenylthio)-cGMP Sodium Salt; 8-CPT-cGMP; Guanosine 3',5'-cyclic monophosphate, 8-(4-chlorophenylthio)-, sodium salt; 8-(4-Chlorophenylthio)-cyclic GMP Sodium Salt; Sodium 8-[(4-chlorophenyl)thio]guanosine-3',5'-cyclic monophosphate; 8-(4-Chlorophenylmercapto)guanosine-3',5'-cyclic monophosphate sodium salt
EINECS	Contact for details

Quality Control

Our 8-(4-Chlorophenylthio)Guanosine 3',5'-Cyclic Monophosphate Sodium Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.